6:42 p.m. ET, May 24, 2021
Most severe effects of MIS-C in children typically resolve within six months, new research suggests
From CNN's Jen Christensen
The most severe symptoms that come with MIS-C, the rare but serious Covid-19-related condition, seem to resolve within six months after hospitalization, according to a new small study of patients at one hospital in London.
The study published Monday in the journal The Lancet Child & Adolescent Health looked at half a year’s worth of results from nearly 46 children who were treated for MIS-C.
Most children in the study didn’t seem to have severe symptoms — stomach problems, inflammation, heart issues, and neurological issues — six months after children had been discharged from the hospital.
A few symptoms lingered for some children in that follow up period. Six children still had stomach problems. Two had some heart abnormalities. One child still had some systematic inflammation. Eighteen of the children had some small neurological abnormalities, but it didn’t seem to impact their ability to carry out everyday tasks.
An assessment of the children’s ability to walk found that 18 of the children were in one of the lowest percentiles for where they were supposed to be developmentally. However, the authors said since there was no comparison group of children who weren’t sick in the study, it’s unclear if this was MIS-C-related. Some earlier studies have shown that the pandemic caused some children developmental delays.
The authors believe some of the children in the study may still need follow up for mental health issues. “Family trauma and anxiety were prominent in our cohort as a direct consequence of the affected child’s illness and familial association with a Covid-19 case,” the study said.
Some children also seemed to have difficulty exercising, due to persistent fatigue. Doctors and parents were encouraged to continue to closely monitor the children.
The authors said that since the study only looked at a small number of children who were at the one hospital, it would be important to expand the research to better understand if these results would be the same for all children who had MIS-C, including those that didn’t need to be hospitalized.
“These findings can hopefully signal cautious optimism that many of the most severe effects of (MIS-C) appear to resolve within six months,” said study co-author, Dr. Justin Penner who works in the pediatric infectious disease department at Great Ormond Street Hospital, the hospital that cared for the children in the study. “However, the persisting fatigue, difficulty exercising, and mental health effects we saw in some children, which can interfere with daily lives, must be closely monitored and patients should continue to be supported by medical teams with a range of specialisms.”