6:35 p.m. ET, May 7, 2021
Common painkillers won't worsen Covid-19, study finds
From CNN's Ryan Prior
People who take common over-the-counter drugs such as ibuprofen or aspirin don’t risk getting sicker from Covid-19, according to a study from researchers at the University of Edinburgh.
When the Covid-19 pandemic began, there was concern that non-steroidal anti-inflammatory drugs (NSAIDs) could cause more severe disease or even raise the risk of death in Covid-19 patients, particularly those with rheumatological disease. The French health ministry issued recommendations that physicians should use acetaminophen instead.
However, subsequent research with evidence from community studies, administrative data, and small studies did not support fears that hospitalized Covid-19 patients fared worse on NSAIDs.
Now this new study, published Friday in the journal Lancet Rheumatology, helps to settle doubts about the effect of NSAIDs on Covid-19 severity.
In the largest study to date on NSAIDs and Covid-19, the researchers enrolled 78,674 patients across 255 health facilities in England, Scotland, and Wales. The evidence was drawn from patients with a confirmed positive or suspected Covid-19 case between Jan. 17 and Aug. 20, 2020.
Just under 6% of them had taken NSAIDs prior to hospital admission. Compared with a similarly sized group of patients who had not taken NSAIDs before going to the hospital, the researchers found that neither patient group was more severe than the other at the time of hospital admission. For example, 30.4% of those who had taken NSAIDs died compared with 31.3% of those who did not.
And their outcomes were similar throughout their hospital stays as well. Use of NSAIDs was not associated with worse in-hospital mortality, critical care admission, requirement for ventilation, requirement for oxygen, or acute kidney injury.
"When the pandemic began over a year ago, we needed to be sure that these common medications would not lead to worse outcomes in people with COVID-19," Dr. Ewen Harrison, a professor of surgery and data science at the University of Edinburgh and lead author of the study, said in a statement. "We now have clear evidence that NSAIDs are safe to use in patients with COVID-19, which should provide reassurance to both clinicians and patients that they can continue to be used in the same way as before the pandemic began."
That means that patients who rely on NSAIDs to relieve conditions such as gout, arthritis, bone pain, and menstrual pain wouldn't have to worry about the drugs worsening a case of Covid-19.
"In conclusion, policy makers should consider reviewing issued advice around NSAID prescribing and COVID-19 severity," the researchers wrote.
However, though NSAIDs may not harm Covid-19 patients, the evidence doesn't lean toward the drugs helping either.
"Although use of NSAIDs could, in theory, be beneficial in patients with COVID-19, we did not identify any evidence to support this," the researchers wrote.