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A tree smashed into a Lake Oswego, Oregon, home after a storm moved through the area on January 16.
CNN  — 

An unrelenting series of winter storms and an outbreak of cold air have killed multiple people across several states since Friday. Now, another round of extreme cold and snow will march across the central and eastern US, setting up more hazardous travel and a brutally cold weekend. Here’s the latest:

More than three dozen storm-related deaths: At least 40 people have died across nine states since January 12. Fatalities have been reported in Arkansas, Illinois, Kansas, Mississippi, New York, Oregon, Pennsylvania, Tennessee and Wisconsin. In Tennessee, where the highest number of weather-related deaths was reported so far, a box truck driver was killed Monday evening when he lost control of the vehicle on a snowy Knoxville highway and careened into a tractor-trailer, police said. Fourteen people were killed across Tenessee due to the severe weather, the state’s emergency management agency said Wednesday, citing the state department of health. Five people died in Pennsylvania when their minivan lost control on a snow-covered I-81, the coroner’s office in Lackawanna County said.

Another round of snow and cold coming: More accumulating snow is likely from the Midwest to the East on Friday. Light totals could once again blanket Washington, DC, and New York City soon after their nearly two-year wait for an inch of snow ended early this week. In the South, winter weather alerts are also in effect across Nashville, Lexington and Charleston, West Virginia, on Thursday. Read on for a more detailed forecast.

• Ice knocks out power, creates treacherous travel in Northwest: Freezing rain and wind pelting the Pacific Northwest knocked out power to more than 85,000 homes and businesses in Oregon Wednesday morning amid frigid temperatures. By Wednesday evening, power outages in Oregon had dropped below 50,000. Icy roadways and downed trees and power lines created dangerous travel conditions that triggered road closures Tuesday night and Wednesday. A nearly 50 mile-stretch of I-84 from west of Portland to the eastern side of the Oregon Cascades was shut down Tuesday night due to the ice threat, according to the state’s department of transportation. That portion remained closed Wednesday evening due to unsafe conditions, and it’s unclear when it will reopen, the Multnomah County Sheriff’s Office said.

Buffalo, New York, drivers face snowy conditions: Lake-effect snow warnings are in effect until Thursday night in Buffalo, where additional snow accumulations of 9 to 18 inches are possible in some areas. The surrounding area could see 1 to 3 feet of localized snowfall and wind gusts up to 40 mph. More than 30 inches of snow had fallen south of Buffalo in Lackawanna, New York, as of Wednesday morning. “Travel could be very difficult to impossible. Areas of blowing snow will significantly reduce visibility. The hazardous conditions will impact the morning commute,” the weather service warned. “Bitter wind chills as low as 10 below zero could result in hypothermia if precautions are not taken.”

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Harsh cold and snow to return

Relief from the cold will be short-lived with another push of bone-chilling air set to arrive across the north-central US late Thursday. The abnormal cold will rush across much of the central and eastern US by Friday afternoon and remain in place for most of the weekend.

High temperatures will struggle to reach the freezing mark in Oklahoma City, Nashville, Philadelphia and New York City on Friday. Chicago won’t be able to break out of the teens and Minneapolis will be stuck in the single digits Friday as the harsh cold settles into place.

Wind chills across the central US will plunge back to dangerous levels by Friday, increasing the risk for frostbite and hypothermia.

Another round of snow will overspread portions of the Midwest and East on Friday as two pieces of atmospheric energy – one of which can be traced back to the Northwest storm – collide. Snow will begin as early as Thursday night in Chicago, and by Friday morning, accumulating snow will stretch into the interior Northeast and central Appalachians.

Cities in the mid-Atlantic and Northeast that just ended record-long snow droughts from an early week storm, including Washington, DC, New York and Philadelphia, will once again have the chance for a light-to-moderate snow.

Around 1 to 3 inches of snow are likely from the Midwest to the East, but some parts of the Appalachians may see totals closer to half a foot by the time snow ends Friday night.

Despite low snowfall amounts, the combination of snow and breezy winds could lead to tricky travel. Additional cancellations and delays are also possible, especially after schools and government offices were shuttered by the similarly impactful early-week storm.

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A person makes his way to the Omni Mount Washington Resort toward the Nikki Haley event during a bad snow storm in Bretton Woods, New Hampshire, on Tuesday, January 16.
Andrew Kelly/Reuters
People walk in New York's Central Park on January 16. Enough snow fell in New York, Philadelphia, Baltimore and Washington, DC, to end nearly two-year-long waits for an inch of snow there.
Mark Zaleski/The Tennessean/USA Today Network
Icicles hang from limestone along Interstate 65 in Nashville, Tennessee, on January 16.
Will Lanzoni/CNN
Snow falls on parked cars in Concord, New Hampshire, on January 16.
Rogelio V. Solis/AP
A worker spreads a composite of ice melter and salt on sidewalks at the Mississippi State Capitol in Jackson on January 16.
Nam Y. Huh/AP
A snow-covered school bus sits in a parking lot in Wheeling, Illinois on January 16. School districts in more than half a dozen states announced closures amid frigid temperatures.
Amanda Andrade-Rhoades/Reuters
People pass through a snowy Rock Creek Park in Washington, DC, on Monday, January 15.
Geoff Stellfox/The Gazette/AP
Isaac Hammond braves subzero temperatures to caucus in Malcolm, Iowa, on January 15. Monday's caucuses were the coldest ever, with high temperatures below zero across much of the state.
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A family waits for their delayed flight at the Austin-Bergstrom International Airport in Austin, Texas, on January 15. Thousands of flights have been canceled or delayed.
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Snow and ice surround the Iowa State Capitol in Des Moines on January 15.
Dan Busey/The TimesDaily/AP
Daniel Cole uses a plastic spoon to clear ice from his vehicle in Florence, Alabama, on January 15.
RJ Sangosti/MediaNews Group/The Denver Post/Getty Images
Crews work to de-ice an airplane at Denver International Airport on January 15.
Jeffrey T. Barnes/AP
Workers remove snow from Highmark Stadium in Orchard Park, New York, on Sunday, January 14. The NFL playoff game between the Buffalo Bills and the Pittsburgh Steelers was pushed back a day due to dangerous blizzard conditions.
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A wrecked tractor-trailer is seen on the eastbound side of Interstate 80 near Williamsburg, Iowa, on January 14.
Barbara J. Perenic/Columbus Dispatch/USA Today Network
A person clears a sidewalk in front of condominiums in Worthington, Ohio, on January 14.
Al Drago/Bloomberg/Getty Images
Cows graze through the snow in Atlantic, Iowa, on Saturday, January 13.
Gary Hershorn/Corbis News/Getty Images
Water from the Hudson River overflows at high tide as a woman jogs in Jersey City, New Jersey, on January 13.
Brendan McDermid/Reuters
Snow and ice dust a worker who was removing snow from a sidewalk in Des Moines on January 13.
Joseph Prezioso/AFP/Getty Images
Storm waves batter coastal homes in Winthrop, Massachusetts, on January 13.
Jim Vondruska/Getty Images
Travelers check their flight status at Chicago's O'Hare Airport, on Friday, January 12. More than 2,000 flights were canceled nationwide because of the winter storm.
Andrew Harnik/AP
Workers shovel sidewalks in Ankeny, Iowa, on January 12. The vast majority of Iowa was under a blizzard warning.
Eric Seals/USA Today
Vehicles slowly make their way along Northwestern Highway in Farmington Hills, Michigan, on January 12.
Antonio Perez/Chicago Tribune/TNS/Zuma
Rebecca Zimmerman walks beside her bicycle on her way to work in Oak Park, Illinois, on January 12.
Erin Hooley/AP
Snow falls on January 12 as migrants in Chicago continue to be housed by the city in "warming" buses.
Will Lanzoni/CNN
Snow piles up outside Drake University's Olmsted Center ahead of CNN's Republican presidential debate in Des Moines on Wednesday, January 10.
Sam Wolfe/Reuters
A man looks over a heavily damaged oak-barrel factory in Bamberg, South Carolina, on January 10, a day after a tornado struck the city.
Bryan Woolston/AP
An employee of the Storm Bros. Ice Cream begins to clean up January 10 after the storm left more than 2 feet of water inside many businesses in downtown Annapolis, Maryland.
Dan Powers/USA Today Network
Kelly-Jo St. Aubin clears snow from the sidewalk outside her home in Kaukauna, Wisconsin, on January 9.
Peter Zay/Anadolu/Getty Images
Firefighters rescue a man after his car was stuck in a flooded area in Charlotte, North Carolina, on January 9.
Spencer Platt/Getty Images
Because of the storm, nearly 2,000 migrants in Brooklyn, New York, were evacuated from tents at Floyd Bennett Field and taken to a local high school on January 9.
Scott Olson/Getty Images
A pedestrian navigates a snow-covered sidewalk in Iowa City, Iowa, on January 9.
Jaide Garcia/CNN
A house is damaged in Panama City Beach, Florida, on January 9. Responders rescued people from structures in Florida's Bay County, where multiple tornadoes hit the ground and caused significant damage and road closures, Bay County Sheriff Tommy Ford said.
Gregg Pachkowski/USA Today Network
Linda Cox looks at her two vehicles that were damaged by a fallen tree in Myrtle Grove, Florida.
Mike De Sisti/The Milwaukee Journal/USA Today Network
Snow covers the trees around the Holy Hill Basilica and National Shrine of Mary in Hubertus, Wisconsin, on January 9.
Joe Raedle/Getty Images
People in Des Moines help push a vehicle back onto the road after it became stuck in the snow on January 9.
SCV/Michael Gordon
Tornado wreckage is seen in Bay County, Florida, on January 9. Twelve tornadoes were reported across Florida, Alabama and Georgia that morning.
Tariq Zehawi/NorthJersey.com/USA Today Network
Workers Brian Henderson and Josko Huljev fill sandbags for residents of Totowa, New Jersey, on January 9. New Jersey Gov. Phil Murphy announced a state of emergency to prepare for the potentially dangerous weather.
Alex Hicks Jr./Spartanburg Herald-Journal/USA Today Network
Flooding is seen at an intersection in Spartanburg, South Carolina, on January 9.

Double whammy of ice and snow in Northwest

Back-to-back storms are delivering a deadly “1-2 punch” to the Northwest with freezing rain and ice in Oregon and Washington and heavy snow through the region’s interior through the end of the week, the weather service said.

At least seven people died in the Portland, Oregon, area since Friday from severe winter weather. Four hypothermia deaths are being investigated in Multnomah County, which includes the city of Portland, county officials told CNN.

Millions in the region were under ice storm warnings early Wednesday, including hard-hit Portland, after a new storm moved onshore Tuesday night. As the severe weather threat persists, Portland Public Schools plan to close Thursday for the third day, the district announced.

Ice and wind combined to bring down trees across the Portland area with deadly effect. A tree came crashing down on an elderly man who was asleep on the second floor of his home, killing him, in Lake Oswego, Oregon, fire marshal Gert Zoutendijk told CNN.

“I don’t have enough words to describe what that looked like,” Lake Oswego Police Chief George Burke said during an emergency city council meeting Tuesday.

Winter storm warnings also extend over the Cascades and northern Rockies. Up to 3 feet of snow could fall over the Cascades through Thursday afternoon and up to 2 feet is possible in higher elevation areas in the northern parts of Washington, Idaho and Montana by late Thursday morning.

CNN’s Nouran Salahieh, Joe Sutton, Aya Elamroussi, Andy Rose, Sarah Dewberry, Raja Razek and Jennifer Henderson contributed to this report.