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(CNN) Dengue fever infects 390 million people each year, and kills as many as 25,000, according to the World Health Organization.
The disease could soon see these numbers decline as the Philippines start administering the world's first dengue vaccine to high-risk children.
The historic drug took 20 years and $1.8 billion to develop. The Philippines' Department of Health launched a school-based immunization program in highly affected areas, making it the first country where the vaccine is commercially available.
Around 70% of dengue fever cases occur in Asia, with the Philippines reporting 200,000 cases in 2013, according to Sanofi.
It's one of the world's most common mosquito-borne viruses, with severe symptoms including headaches, rashes and leaking blood vessels.
The makers of the vaccine are confident it can reduce cases in the Philippines by 24% over the next five years.
Read: Dengue fever, How a mosquito infected millions
Dengue fever: How a mosquito infected millions
Dengue virus is carried by the Aedes aegypti mosquito, the same type that can spread Zika virus. A bite from a mosquito harboring the virus can result in headaches, rashes and severe joint pains. In serious cases, it can cause internal bleeding and death.
There is no drug for dengue. Patients must be monitored carefully for the onset of the severe form of dengue. Pictured, a nurse looks after a patient with dengue at a hospital in Manila, Philippines.
The main control measures for dengue to date have been to reduce the numbers of mosquitoes by large-scale spraying of insecticides. The chemicals have been deployed in both residential and public spaces in a mass culling of the insects spreading the disease.
Urbanization has aided the spread of dengue, with more than 100 countries now endemic for the disease. Pictured, containers, bottles and tires are perfect breeding sites for Aedes aegypti mosquitoes that transmit the dengue virus. The versatile mosquitoes can lay eggs on any shallow surface of water.
Public spraying of insecticides is based on seasonal changes, with more cases expected during rainy seasons in the tropics. But the measures haven't proven to curb the spread of disease adequately.
Experts believe a vaccine is needed to truly control the disease. A dengue vaccine, called Dengvaxia, recently became available in Mexico, Brazil, the Philippines and El Salvador.